Calcium-based Dendritic Excitability and Its Regulation in the 5 Deep Cerebellar Nuclei
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چکیده
1 2 3 4 CALCIUM-BASED DENDRITIC EXCITABILITY AND ITS REGULATION IN THE 5 DEEP CEREBELLAR NUCLEI 6 7 Eve R. Schneider*, Eugene F. Civillico, Samuel S.-H. Wang 8 9 Department of Psychology, Department of Molecular Biology, and Princeton Neuroscience 10 Institute, Princeton University 11 12 13 14 Author contributions: 15 Eve Schneider, Eugene Civillico and Sam Wang designed the experiments. 16 Eve Schneider and Eugene Civillico performed the experiments. 17 Eve Schneider, Eugene Civillico and Sam Wang analyzed the data. 18 Eve Schneider, Eugene Civillico and Sam Wang wrote the paper. 19 20 Corresponding author: Samuel S.-H. Wang 21 Address: Department of Molecular Biology, Lewis Thomas Laboratory, Washington Road, 22 Princeton University, Princeton NJ, 08544. 23 *Current address: Department of Cellular & Molecular Physiology, Sterling Hall of Medicine, B24 Wing, 333 Cedar Street Room 156, Yale School of Medicine, New Haven, CT 06510. 25 26 Running head: Regulation of calcium spikes in DCN dendrites 27 28
منابع مشابه
Contribution of Somatic and Dendritic SK Channels in the Firing Rate of Deep Cerebellar Nuclei: Implication in Cerebellar Ataxia
Introduction: Loss of inhibitory output from Purkinje cells leads to hyperexcitability of the Deep Cerebellar Nuclei (DCN), which results in cerebellar ataxia. Also, inhibition of small-conductancecalcium-activated potassium (SK) channel increases firing rate f DCN, which could cause cerebellar ataxia. Therefore, SK channel activators can be effective in reducing the symptoms of this disease, ...
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تاریخ انتشار 2013